Merel Adjobo-Hermans, PhD

 
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Address:
Radboud University Nijmegen Medical Centre NCMLS
Department of Biochemistry
Geert Grooteplein 28
6525 GA Nijmegen
The Netherlands

MAIN AREAS OF RESEARCH

Application and development of highly advanced fluorescence microscopy techniques to study signaling in living cells.

Research Experience

2009-present Junior Principal Investigator at the Nijmegen Centre for Molecular Life Sciences, Department of Biochemistry, Radboud University Nijmegen Medical Centre.

2007-2008 Postdoctoral fellow at the Swammerdam Institute for Life Sciences, Section of Molecular Cytology, University of Amsterdam, The Netherlands, funded by the FP6 European Union Molecular Imaging Integrated Project ‘Integrated Technologies for In-Vivo Molecular Imaging’.

15/05/2002-15/03/2007 PhD student at the Swammerdam Institute for Life Sciences, Section of Molecular Cytology, University of Amsterdam, The Netherlands., PhD supervisor: Prof. Dr. TWJ Gadella Jr.

Most important 5-10 publications

Adjobo-Hermans, M.J.W., Crosby, K.C., Putyrski, M., Bhageloe, A., van Weeren, L., Schultz, C., Goedhart, J. and T.W.J. Gadella Jr. (2012) PLCb isoforms differ in their subcellular location and their CT-domain dependent interaction with Gaq. Cellular Signaling 25(1), p.255

Chung, Y., Sinzinger, M.D., Bovee-Geurts, P., Krause, M., Dinkla, S., Joosten, I., Koopman, W.J., Adjobo-Hermans, M.J.W. and R. Brock (2011) Analyzing the Homeostasis of Signaling Proteins by a Combination of Western Blot and Fluorescence Correlation Spectroscopy. Biophysical Journal 101(11), p.2807.

Goedhart, J., van Weeren, L., Adjobo-Hermans, M.J.W., Elzenaar, I., Hink, M.A. and T.W.J. Gadella Jr. (2011) Quantitative Co-Expression of Proteins at the Single Cell Level – Application to a Multimeric FRET Sensor. PLoS One 6(11): e27321

Adjobo-Hermans, M.J.W., Goedhart, J., van Weeren, L., Nijmeijer, S., Manders, E.M.M., Offermanns, S. and T.W.J. Gadella Jr. (2011) Real-time visualization of heterotrimeric G protein Gq activation in living cells. BMC Biology9: 32.

Adjobo-Hermans, M.J.W., Goedhart, J. and T.W.J. Gadella Jr. (2008) Regulation of PLCb1a membrane-anchoring by PIP2. Journal of Cell Science 121, p.3770.

Goedhart, J., Vermeer, J.E., Adjobo-Hermans, M.J.W., van Weeren, L. and T.W.J. Gadella Jr. (2007) Sensitive detection of p65 homodimers using red-shifted and fluorescent protein-based FRET couples. PLoS One 2(10): e1011.